Substrate: Insulin receptor substrate 2 (Adaptor molecule)
Seq-ID: P81122 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-58556   NUCL_MOUSE
MINT-58581   ZN592_MOUSE
MINT-58761   LYN_MOUSE
MINT-60762   INSR_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase binding,
signal transducer activity		 cytosol brain development,
negative regulation of kinase activity,
positive regulation of insulin secretion,
positive regulation of mesenchymal cell proliferation,
positive regulation of B cell proliferation,
positive regulation of cell migration,
response to glucose stimulus,
mammary gland development,
negative regulation of B cell apoptosis,
insulin receptor signaling pathway,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 624 ASSPKVAYNPYPEDYGDIEIG INSR 9195949
LTP
1.00
 - -
0.54
 - medium
Y 628 KVAYNPYPEDYGDIEIGSHKS INSR 9195949
LTP
0.15
 - -
0.56
 - medium

Substrate: Insulin receptor substrate 2 (Adaptor molecule)
Seq-ID: ENSP00000365016 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
receptor activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 309 EFRPRSKSQSSGSSATHPISV - 17081983
HTP
 - - -
0.66
 - medium
S 388 AGARPVSVAGSPLSPGPVRAP - 17081983
HTP
 - - -
0.78
 - medium
S 391 RPVSVAGSPLSPGPVRAPLSR - 17081983
HTP
 - - -
0.80
 - medium
S 560 SHCGRSYRRVSGDAAQDLDRG - 17081983
HTP
 - - -
0.63
 - medium
S 594 QRPVPQPSSASLDEYTLMRAT - 17081983
HTP
 - - -
0.65
 - medium
S 736 GYKASSPAESSPEDSGYMRMW - 17081983
HTP
 - - -
0.55
 - medium
S 973 PGTSSDSRQRSPLSDYMNLDF - 17081983
HTP
 - - -
0.84
 - medium
S 1174 SFAHNPKRHNSASVENVSLRK - 17081983
HTP
 - - -
0.82
 - medium
S 1176 AHNPKRHNSASVENVSLRKSS - 17081983
HTP
 - - -
0.84
 - medium

Substrate: Insulin receptor substrate 2 (Adaptor molecule)
Seq-ID: Q9Y4H2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-18053   IGF1R_HUMAN
MINT-18199   INSR_HUMAN
MINT-50999   1433B_HUMAN
MINT-3295882   1433Z_HUMAN
MINT-3975441   1433S_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
signal transducer activity plasma membrane,
cytosol		 negative regulation of kinase activity,
positive regulation of insulin secretion,
positive regulation of B cell proliferation,
positive regulation of fatty acid beta-oxidation,
response to glucose stimulus,
lipid homeostasis,
positive regulation of glycogen biosynthetic process,
negative regulation of plasma membrane long-chain fatty acid transport,
negative regulation of B cell apoptosis,
insulin receptor signaling pathway,
positive regulation of glucose import,
glucose metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 75 GSAPQPPRLEYYESEKKWRSK - 18083107
HTP
1.00
 - PH
0.64
 - medium
Y 184 SAGAAGAEDSYGLVAPATAAY - 18669648
HTP
1.00
 - -
0.26
 - medium
S 304 LKELFEFRPRSKSQSSGSSAT IKK_group 12351658
LTP
1.00
 - -
0.53
 - medium
S 306 ELFEFRPRSKSQSSGSSATHP IKK_group 12351658
LTP
1.00
 - -
0.58
 - medium
S 306 ELFEFRPRSKSQSSGSSATHP - 18669648
HTP
1.00
 - -
0.58
 - medium
S 308 FEFRPRSKSQSSGSSATHPIS - 18669648
HTP
1.00
 - -
0.64
 - medium
S 312 PRSKSQSSGSSATHPISVPGA - 18669648
HTP
0.02
 - -
0.76
 - medium
S 334 RHHHLVNLPPSQTGLVRRSRT - 17525332
HTP
1.00
 - -
0.67
 - medium
S 346 TGLVRRSRTDSLAATPPAAKC - 16964243
HTP
1.00
 - -
0.61
 - medium
S 346 TGLVRRSRTDSLAATPPAAKC - 18669648
HTP
1.00
 - -
0.61
 - medium
T 350 RRSRTDSLAATPPAAKCSSCR - 16964243
HTP
1.00
 - -
0.56
 - medium
T 350 RRSRTDSLAATPPAAKCSSCR - 18669648
HTP
1.00
 - -
0.56
 - medium
T 363 AAKCSSCRVRTASEGDGGAAA - 18669648
HTP
1.00
 - -
0.61
 - medium
S 365 KCSSCRVRTASEGDGGAAAGA - 18220336
HTP
1.00
 - -
0.60
 - medium
S 365 KCSSCRVRTASEGDGGAAAGA - 18669648
HTP
1.00
 - -
0.60
 - medium
S 384 GAAAAGARPVSVAGSPLSPGP IKK_group 12351658
LTP
1.00
 - -
0.74
 - medium
S 384 GAAAAGARPVSVAGSPLSPGP - 18669648
HTP
1.00
 - -
0.74
 - medium
S 388 AGARPVSVAGSPLSPGPVRAP IKK_group 12351658
LTP
1.00
 - -
0.78
 - medium
S 388 AGARPVSVAGSPLSPGPVRAP - 18088087
HTP
1.00
 - -
0.78
 - medium
S 388 AGARPVSVAGSPLSPGPVRAP - 18220336
HTP
1.00
 - -
0.78
 - medium
S 388 AGARPVSVAGSPLSPGPVRAP - 18669648
HTP
1.00
 - -
0.78
 - medium
S 391 RPVSVAGSPLSPGPVRAPLSR - 18088087
HTP
1.00
 - -
0.80
 - medium
S 391 RPVSVAGSPLSPGPVRAPLSR - 18220336
HTP
1.00
 - -
0.80
 - medium
S 391 RPVSVAGSPLSPGPVRAPLSR - 18669648
HTP
1.00
 - -
0.80
 - medium
S 518 GDLRAFCSHRSNTPESIAETP - 18669648
HTP
1.00
 - -
0.73
 - medium
T 520 LRAFCSHRSNTPESIAETPPA - 15302935
HTP
1.00
 - -
0.75
 - medium
T 520 LRAFCSHRSNTPESIAETPPA - 18669648
HTP
1.00
 - -
0.75
 - medium
S 523 FCSHRSNTPESIAETPPARDG - 18669648
HTP
1.00
 - -
0.84
 - medium
T 527 RSNTPESIAETPPARDGGGGG - 16964243
HTP
1.00
 - -
0.90
 - medium
T 527 RSNTPESIAETPPARDGGGGG - 18669648
HTP
1.00
 - -
0.90
 - medium
S 550 YGYMTMDRPLSHCGRSYRRVS - 18669648
HTP
0.08
 - -
0.49
 - medium
S 560 SHCGRSYRRVSGDAAQDLDRG - 18669648
HTP
0.13
 - -
0.63
 - medium
S 577 LDRGLRKRTYSLTTPARQRPV IKK_group 12351658
LTP
1.00
 - -
0.77
 - medium
S 577 LDRGLRKRTYSLTTPARQRPV - 16964243
HTP
1.00
 - -
0.77
 - medium
S 577 LDRGLRKRTYSLTTPARQRPV - 18220336
HTP
1.00
 - -
0.77
 - medium
S 577 LDRGLRKRTYSLTTPARQRPV - 18669648
HTP
1.00
 - -
0.77
 - medium
T 579 RGLRKRTYSLTTPARQRPVPQ - 18669648
HTP
0.20
 - -
0.79
 - medium
T 580 GLRKRTYSLTTPARQRPVPQP - 16964243
HTP
1.00
 - -
0.80
 - medium
T 580 GLRKRTYSLTTPARQRPVPQP - 18669648
HTP
1.00
 - -
0.80
 - medium
S 594 QRPVPQPSSASLDEYTLMRAT - 18669648
HTP
1.00
 - -
0.65
 - medium
S 608 YTLMRATFSGSAGRLCPSCPA - 18088087
HTP
0.07
 - -
0.38
 - medium
S 608 YTLMRATFSGSAGRLCPSCPA - 18669648
HTP
0.07
 - -
0.38
 - medium
S 620 GRLCPSCPASSPKVAYHPYPE - 18669648
HTP
1.00
 - -
0.44
 - medium
Y 653 SSSNLGADDGYMPMTPGAALA - 16497976
HTP
1.00
 PIK3R1 SH2 -
0.60
 - medium
Y 653 SSSNLGADDGYMPMTPGAALA - 18083107
HTP
1.00
 PIK3R1 SH2 -
0.60
 - medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 16497976
HTP
1.00
 PIK3R1 SH2 -
0.59
 - medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 18083107
HTP
1.00
 PIK3R1 SH2 -
0.59
 - medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 18669648
HTP
1.00
 PIK3R1 SH2 -
0.59
 - medium
S 679 SCRSDDYMPMSPASVSAPKQI - 18669648
HTP
1.00
 - -
0.60
 - medium
T 713 PSAGPAGPAPTSAAGRTFPAS - 18220336
HTP
 - - -
0.69
 - medium
T 713 PSAGPAGPAPTSAAGRTFPAS - 18669648
HTP
 - - -
0.69
 - medium
S 714 SAGPAGPAPTSAAGRTFPASG - 18669648
HTP
 - - -
0.68
 - medium
S 730 FPASGGGYKASSPAESSPEDS - 18669648
HTP
0.10
 - -
0.71
 - medium
S 731 PASGGGYKASSPAESSPEDSG - 18669648
HTP
1.00
 - -
0.70
 - medium
S 735 GGYKASSPAESSPEDSGYMRM - 18669648
HTP
0.02
 - -
0.57
 - medium
S 736 GYKASSPAESSPEDSGYMRMW - 18669648
HTP
0.25
 - -
0.55
 - medium
Y 742 PAESSPEDSGYMRMWCGSKLS - 18083107
HTP
1.00
 PIK3R1 SH2 -
0.49
 - medium
S 770 LLPNGDYLNVSPSDAVTTGTP - 18220336
HTP
1.00
 - -
0.66
 - medium
S 770 LLPNGDYLNVSPSDAVTTGTP - 18669648
HTP
1.00
 - -
0.66
 - medium
S 772 PNGDYLNVSPSDAVTTGTPPD - 18220336
HTP
0.11
 - -
0.65
 - medium
S 772 PNGDYLNVSPSDAVTTGTPPD - 18669648
HTP
0.11
 - -
0.65
 - medium
T 777 LNVSPSDAVTTGTPPDFFSAA - 18669648
HTP
0.14
 - -
0.59
 - medium
T 779 VSPSDAVTTGTPPDFFSAALH - 18669648
HTP
0.29
 - -
0.63
 - medium
Y 823 PYTCGGDSDQYVLMSSPVGRI - 16497976
HTP
0.47
 PIK3R1 SH2 -
0.46
 - medium
Y 823 PYTCGGDSDQYVLMSSPVGRI - 18083107
HTP
0.47
 PIK3R1 SH2 -
0.46
 - medium
S 828 GDSDQYVLMSSPVGRILEEER - 18669648
HTP
0.25
 - -
0.57
 - medium
S 894 RGRAVRPTRLSLEGLPSLPSM - 18669648
HTP
1.00
 - -
0.71
 - medium
S 915 HEYPLPPEPKSPGEYINIDFG - 15302935
HTP
1.00
 - -
0.74
 - medium
S 915 HEYPLPPEPKSPGEYINIDFG - 18088087
HTP
1.00
 - -
0.74
 - medium
S 915 HEYPLPPEPKSPGEYINIDFG - 18220336
HTP
1.00
 - -
0.74
 - medium
S 915 HEYPLPPEPKSPGEYINIDFG - 18669648
HTP
1.00
 - -
0.74
 - medium
Y 919 LPPEPKSPGEYINIDFGEPGA - 18669648
HTP
1.00
 GRB2 SH2 -
0.77
 - medium
S 973 PGTSSDSRQRSPLSDYMNLDF - 18669648
HTP
0.39
 - -
0.84
 - medium
S 1100 PPKPEAARVASPTSGVKRLSL - 15302935
HTP
1.00
 - -
0.80
 - medium
S 1100 PPKPEAARVASPTSGVKRLSL - 16964243
HTP
1.00
 - -
0.80
 - medium
S 1100 PPKPEAARVASPTSGVKRLSL - 18088087
HTP
1.00
 - -
0.80
 - medium
S 1100 PPKPEAARVASPTSGVKRLSL - 18669648
HTP
1.00
 - -
0.80
 - medium
S 1103 PEAARVASPTSGVKRLSLMEQ - 18669648
HTP
0.26
 - -
0.76
 - medium
S 1109 ASPTSGVKRLSLMEQVSGVEA - 18669648
HTP
0.07
 - -
0.67
 - medium
S 1148 ADPQGGRRRHSSETFSSTTTV - 18669648
HTP
1.00
 - -
0.91
 - medium
S 1149 DPQGGRRRHSSETFSSTTTVT - 15364919
LTP
1.00
 - -
0.91
 - medium
S 1149 DPQGGRRRHSSETFSSTTTVT - 18669648
HTP
1.00
 - -
0.91
 - medium
T 1151 QGGRRRHSSETFSSTTTVTPV - 18669648
HTP
1.00
 - -
0.89
 - medium
T 1159 SETFSSTTTVTPVSPSFAHNP - 18669648
HTP
1.00
 - -
0.81
 - medium
S 1162 FSSTTTVTPVSPSFAHNPKRH - 18669648
HTP
0.21
 - -
0.84
 - medium
S 1164 STTTVTPVSPSFAHNPKRHNS - 18669648
HTP
1.00
 - -
0.85
 - medium
S 1174 SFAHNPKRHNSASVENVSLRK - 18669648
HTP
1.00
 - -
0.82
 - medium
S 1176 AHNPKRHNSASVENVSLRKSS - 18220336
HTP
1.00
 - -
0.84
 - medium
S 1176 AHNPKRHNSASVENVSLRKSS - 18669648
HTP
1.00
 - -
0.84
 - medium
S 1185 ASVENVSLRKSSEGGVGVGPG - 18669648
HTP
0.07
 - -
0.83
 - medium
T 1202 VGPGGGDEPPTSPRQLQPAPP - 18669648
HTP
 - - -
0.97
 - medium
S 1203 GPGGGDEPPTSPRQLQPAPPL - 15302935
HTP
 - - -
0.98
 - medium
S 1203 GPGGGDEPPTSPRQLQPAPPL - 18669648
HTP
 - - -
0.98
 - medium
S 1283 PPLPQPGDKSSWGRTRSLGGL - 18669648
HTP
0.07
 - -
0.84
 - medium

Valid HTML 4.01 Transitional